As Published in Novus Light Technologies TodayA piezo-actuated device called a solution switcher allows researchers to investigate fast (millisecond) signaling dynamics involving the binding of agonist molecules like glutamate to cell membrane receptors. Read about why and how it is important to avoid exciting ringing vibrations in the switcher assembly. (read more ....)
As Published in Laser Focus WorldHigh optomechanical stability is the key to discriminating nonstandard-shaped cells with trace variance in fluorescence intensity. (read more ....)
As Published in Novus LightThe new MMF.sd “optical mount flipper” from Siskiyou Corporation is a motorized platform that enables optical components to be rapidly moved in and out of a free space beam path. (read more ....)
As Published in Novus LightLab jacks from Siskiyou Corporation offer an unmatched combination of stability, platform parallelism (over their full range of travel) and large adjustment range. (read more ....)
A comprehensive understanding of how the central nervous system communicates with and controls muscle function requires unraveling the precise roles of neurotransmitters—.
(read more ....)
As Published in Novus LightIVM Series kinematic optical mounts from Siskiyou utilize a patented, spring-loaded pivot construction to deliver two-axis tilt adjustment with zero crosstalk and longterm mechanical stability. (read more ....)
Optimizing Probe Positioning for Life Science Research
by John Wingerd | November 2018
Photonics technologies enable life scientists to probe samples in the increasingly sophisticated study of processes ranging from neuron signaling to heart muscle contraction, as well
as cells and cellular development. As research continues at increasingly finer levels of resolution, the requirements for optomechanical positioning become ever more demanding.
Positioning equipment manipulates the probes used to interact with biological samples. This includes positioning a light probe, such as a focused laser or LED, and positioning a physical
probe, such as an electrode or microsyringe.
Custom Optomechanics in Industrial UV Lasers
by John Wingerd | November 2018
Reliability and longevity directly impact the cost of using Q-switched, diode pumped, solid state, ultraviolet lasers in industrial applications. Damage to
the intracavity harmonic crystal is often the major limiting factor in the lifetime of these lasers.
As Published in Novus LightA new motion controller system from Siskiyou features LabView control, a simplified virtual interface and the ability to automatically create scripts. (read more ....)
As Published in Novus LightA new series of single axis platform flexures from Siskiyou Corporation offer highly stable, economical mounting of optical components, along with single axis tilt adjustment. (read more ....)
As Published in Novus LightLee Laser (now part of Coherent) built a successful business featuring lamp-pumped and then diode-pumped (i.e., DPSS) solid state lasers, with powers up to 100 watts. In a field with multiple low-cost competitors, Lee Laser was able to effectively differentiate their brand as a supplier of affordable industrial lasers featuring “workhorse” reliability. Prior to the company’s acquisition by Coherent, Lee saw this brand image threatened when some of their side-pumped DPSS lasers failed to work to specification when received by the customer. Because of the importance of reliability to their industrial customers and to Lee’s market leadership, the company set out to identify and eradicate the source(s) of these failures. (read more ....)
While optical microscopy methods for neuroscience have expanded significantly in recent times, traditional tools such as patch clamp technology are still widely used because they provide superior data for many types of experiments. Researchers at the AstraZeneca-Tufts Laboratory for Basic and Translational Research are using patch clamp technology to study fundamental aspects of synaptic inhibition that are associated with epileptic-type seizures. This Institute itself is an exciting new business model in the world of neuroscience research, created as a joint collaborative venture between a leading academic institution and a highly respected pharmaceutical giant. (read more .....
From neuroscience to morphogenesis and photosynthesis, optomechanical modules allow researchers to utilize fluorescence microscopy in diverse and increasingly complex studies.
(read more ....)
functionality of optical microscopes from all major manufacturers (Zeiss, Nikon, Olympus), or even for building a new microscope. (read more...)
The stages are compatible with both manual and motorized actuators from Siskiyou, including 80 TPI and 100 TPI pitch screws, an ultrahigh resolution differential micrometer, and the company’s 512 series motorized actuators. Applications include microscopy, intracavity adjustments in laser, and medical device incorporation. (read more ....)
Comparing Micromanipulators for Electrophysiology
Several different technologies offer a range of performance options within the confines of an optical microscope for patch-clamp studies, intracellular recording and other demanding experiments in electrophysiology. (read more ....)
Boosting conventional microscopes for optogenetics
A simple, modular optomechanical tool breaks barriers by enabling the seamless addition and control of a secondary light source in standard microscopy setups. The cost-efficient tool facilitates not only photoactivation for optogenetics, but also extends microscope imaging capabilities. (read more ....)
GRANTS PASS, Or., Aug. 17, 2015 - Although product miniaturization can confer numerous practical advantages, it may create significant design issues - hurdles that need to be overcome to make the miniaturization a reality. Siskiyou Corp., a supplier of positioning equipment for life sciences and which specializes in building hardware for space- and access-restricted applications, has just solved such an obstacle. (read more....)
Optical mounts frequently play a critical role in overall laser system performance. Yet their impact often becomes obvious only when system operation degrades due to optical misalignment induced by vibration, thermal drift or long term mechanical creep in mounts. This article reviews basic styles of optical mount design and construction, and compares various mount types in terms of their stability, functionality and cost. (Read More ....)
Electrophysiology encompasses the measurement and analysis of transient ion flows and resultant voltage changes across cellular membranes, e.g., sodium ion channels that enable nerve cell signal transmission. A key, but often unheralded, component of these experiments is the micromanipulation system used by the researcher to maneuver the micropipettes (Read More....)
3/16/15 – Siskiyou Corporation has expanded their Class 1000 cleanroom manufacturing space to encompass approximately 20% of their Grants Pass, OR, production facility, enabling the company to better meet the needs of OEMs incorporating Siskiyou’s products into high value optical assemblies. Specifically, the new cleanroom facilities, (Read More ...)
Siskiyou Corporation has been awarded a US Patent (Patent No. 8,925,409) for a novel actuating mechanism that significantly improves the performance of top adjusted optical mounts and linear translation stages. Specifically, the Siskiyou invention mechanically isolates the rotation motion of the adjustment screw from the moving part of the mount or stage, so that turning the adjustor imparts only linear, (read more ....)
2/16/15 – The Siskiyou IS-OGP is a simple, turnkey, modular solution (patent pending) for integrating an external laser beam into an existing microscope in optogenetics experiments that utilize a laser spot to stimulate target neurons in the cortex of lab animals. Specifically, the IS‑OGP provides a means to introduce a fiber-coupled laser beam into the infinity space of leading optical microscopes having a trinocular setup (read more ....)